Abnormalities of antioxidant metabolism in a case of Friedreich's disease.

@article{Helveston1996AbnormalitiesOA,
  title={Abnormalities of antioxidant metabolism in a case of Friedreich's disease.},
  author={W. Helveston and J. Cibula and R. Hurd and B. Uthman and B. Wilder},
  journal={Clinical neuropharmacology},
  year={1996},
  volume={19 3},
  pages={
          271-5
        }
}
We report a patient with Friedreich's disease (FD) who exhibited abnormalities of antioxidant metabolism, including decreased levels of glutathione peroxidase, glutathione reductase, and selenium, and an increased lipid peroxide index. These abnormalities became normal after treatment with N-acetylcysteine, selenium, and low-dose vitamin E therapy. Treatment was associated with a decreased rate of clinical decline. FD is a neurodegenerative disorder that may be related to disturbed antioxidant… Expand
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