Abnormalities of Doppler measures of diastolic function in the healthy elderly are not related to alterations of left atrial pressure.

BACKGROUND Normal healthy aging results in changes in Doppler indexes of diastolic function. One widely accepted explanation for these alterations that is based on animal data is an age-associated impairment of myocardial relaxation resulting from abnormal myocyte calcium handling. However, an alternative theory based on altered left atrial compliance with… CONTINUE READING