Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome

@article{Doerner2002AbnormalitiesOB,
  title={Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sj{\"o}gren's syndrome},
  author={Thomas Doerner and Peter E Lipsky},
  journal={Arthritis Research},
  year={2002},
  volume={4},
  pages={360 - 371}
}
Primary Sjögren's syndrome (pSS) is an autoimmune disorder characterized by specific pathologic features and the production of typical autoantibodies. In addition, characteristic changes in the distribution of peripheral B cell subsets and differences in use of immunoglobulin variable-region genes are also features of pSS. Comparison of B cells from the blood and parotid gland of patients with pSS with those of normal donors suggests that there is a depletion of memory B cells from the… CONTINUE READING
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Comparison of heavy chain rearrangements in the blood and parotid gland of a patient with Sjögren’s syndrome

  • A Hansen, AM Jacobi, GR Burmester, PE Lipsky, T Dörner
  • Scand J Immunol
  • 2002
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