Abnormalities induced by the mutant gene, lpr. Patterns of disease and expression of murine leukemia viruses in SJL/J mice homozygous and heterozygous for lpr

Abstract

SJL/J mice heterozygous or homozygous for the lpr mutation were compared with SJL/J-+/+ mice for longevity, histopathology, antigenic characteristics of lymphocytes and expression of murine leukemia viruses (MuLV). In comparison to +/+ mice, lpr homozygotes had a markedly shortened life span, died with infiltrative pulmonary disease, but little or no renal… (More)

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@article{Morse1985AbnormalitiesIB, title={Abnormalities induced by the mutant gene, lpr. Patterns of disease and expression of murine leukemia viruses in SJL/J mice homozygous and heterozygous for lpr}, author={Herbert C. Morse and John B. Roths and Walter F. Davidson and Wallace Y Langdon and Tammy Fredrickson and J. Hartley}, journal={The Journal of Experimental Medicine}, year={1985}, volume={161}, pages={602 - 616} }