Abnormalities in the T and NK lymphocyte phenotype in patients with Nijmegen breakage syndrome.

@article{Michakiewicz2003AbnormalitiesIT,
  title={Abnormalities in the T and NK lymphocyte phenotype in patients with Nijmegen breakage syndrome.},
  author={Jacek Michałkiewicz and Christine Barth and Krystyna H. Chrzanowska and Hanna Gregorek and Małgorzata Syczewska and Corry Weemaes and Kazimierz Madaliński and J{\'o}zef Stachowski},
  journal={Clinical and experimental immunology},
  year={2003},
  volume={134 3},
  pages={482-90}
}
Nijmegen breakage syndrome (NBS) is a rare autosomal recessive disorder characterized by spontaneous chromosomal instability with predisposition to immunodeficiency and cancer. In order to assess the cellular basis of the compromised immune response of NBS patients, the distribution of functionally distinct lymphocyte subsets in peripheral blood was evaluated by means of double-colour flow cytometry. The study involved the 36 lymphopenic patients with a total lymphocyte count < or =1500 microl… CONTINUE READING

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