Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation

@article{Croze2015AbnormalitiesIM,
  title={Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation},
  author={Marine L. Croze and Alain G{\'e}lo{\"e}n and Christophe O Soulage},
  journal={British Journal of Nutrition},
  year={2015},
  volume={113},
  pages={1862 - 1875}
}
We previously reported that a chronic supplementation with myo-inositol (MI) improved insulin sensitivity and reduced fat accretion in mice. [...] Key Result HFD (60 % energy from fat) feeding was associated with inosituria and inositol intra-tissue depletion in the liver and kidneys. MI supplementation (0·58 mg/g per d) restored inositol pools in kidneys (partially) and liver (fully).Expand
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TLDR
How a short period of supplementation with inositols is able to ameliorate the HFD-induced electrical, structural and functional heart alterations including ventricular remodeling is shown, for the first time, in the mouse model of high fat diet induced obesity. Expand
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TLDR
It is suggested that MI and PB may improve insulin intracellular signalling in adipose tissue but this did not translate to meaningful differences in glucose tolerance. Expand
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TLDR
Combined inositol treatment during pregnancy improves blood pressure, glucose levels at the glucose tolerance test, and metabolic biomarkers relevant to diabetes and obesity in metabolic-like syndrome pregnant mice and in obese pregnant mice. Expand
Intake of phytic acid and myo-inositol lowers hepatic lipogenic gene expression and modulates gut microbiota in rats fed a high-sucrose diet.
TLDR
It is suggested that dietary PA downregulates hepatic lipogenic gene expression and modulates gut microbiota composition in rats feeding an HSC diet but not in rats fed an HSR diet, and the MI ring of PA may be responsible for the effects. Expand
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Communities eating a western-like diet, rich in fat, sugar and significantly deprived of fibers, share a relevant increased risk of both metabolic and cancerous diseases and underappreciated mechanisms may likely account for acquired, metabolic deficiency in inositol bioavailability. Expand
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TLDR
This review intends to provide information about the meaning of dietary MI in animal metabolism as well as to discuss potential implications of dietaryMI in poultry health and performance with the aim to identify open questions in poultry research. Expand
Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic Rats
TLDR
Combined IP6 and inositol supplement consumption may protect people with diabetes from increased risk of cardiovascular diseases due to the supplement's ability to maintain red cell distribution width percentage towards the normal control group. Expand
A review of the role of inositols in conditions of insulin dysregulation and in uncomplicated and pathological pregnancy.
TLDR
The role and function of inositols within the maternal-placental-fetal axis in both uncomplicated and pathological pregnancies is examined, and it is suggested that inositol play a vital role in promoting healthy pregnancy. Expand
Inositols in Insulin Signaling and Glucose Metabolism
TLDR
Clinical data support the beneficial effects exerted by inositol by reducing glycaemia levels and hyperinsulinemia and buffering negative effects of sustained insulin stimulation upon the adipose tissue and the endocrine system, and myoIns has become a reliable treatment option, as opposed to hormonal stimulation, for insulin-resistant PCOS patients. Expand
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