Abnormalities in hepatic lipase in chronic renal failure: role of excess parathyroid hormone.

@article{Klin1996AbnormalitiesIH,
  title={Abnormalities in hepatic lipase in chronic renal failure: role of excess parathyroid hormone.},
  author={Mikhail Klin and Miroslaw T Smogorzewski and Zehmin Ni and Guoqiang Zhang and Shaul G. Massry},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 10},
  pages={2167-73}
}
Post-heparin hepatic lipase activity is reduced in chronic renal failure (CRF). This could be due to reduced synthesis, decreased activity, and/or impaired secretion of the enzyme. Further, the factor(s) responsible for such derangements are not elucidated. We examined hepatic lipase metabolism in normal, 6-wk-old CRF rats, CRF-PTX (parathyroidectomized) rats, and CRF and normal rats treated with verapamil (CRF-V, normal-V) using liver homogenate, hepatic cell culture for 8 h, and in vitro… CONTINUE READING