Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development.

Abstract

Diethylstilbestrol (DES) was administered neonatally (Days 2-12; 10 microg on alternate days) to rats, and developmental changes in Sertoli cell function were evaluated at 18, 25, and 35 days of age and compared to those observed in rats administered a GnRH antagonist (GnRHa; Days 2 and 5; 10 mg/kg) or a vehicle (controls). DES and GnRHa treatments resulted… (More)

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@article{Sharpe1998AbnormalitiesIF, title={Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development.}, author={Richard M. Sharpe and Nina Atanassova and Chris Mckinnell and Priyanka Parte and Kevin Turner and Jane S Fisher and Jeffrey Kerr and Nigel Patrick Groome and Sheila Macpherson and Michael R. Millar and Philippa T K Saunders}, journal={Biology of reproduction}, year={1998}, volume={59 5}, pages={1084-94} }