Abnormalities in early markers of muscle involvement support a delay in myogenesis in spinal muscular atrophy.

@article{MartnezHernndez2014AbnormalitiesIE,
  title={Abnormalities in early markers of muscle involvement support a delay in myogenesis in spinal muscular atrophy.},
  author={Rebeca Mart{\'i}nez-Hern{\'a}ndez and Sara M Bernal and Laura Al{\'i}as and Eduardo F. Tizzano},
  journal={Journal of neuropathology and experimental neurology},
  year={2014},
  volume={73 6},
  pages={
          559-67
        }
}
Spinal muscular atrophy (SMA) is characterized by loss of motor neurons in the spinal cord that results in muscle denervation and profound weakness in affected patients. We sought evidence for primary muscle involvement in the disease during human development by analyzing the expression of several muscle cytoskeletal components (i.e. slow, fast, and developmental myosin, desmin, and vimentin) in fetal or postnatal skeletal muscle samples from 5 SMA cases and 6 controls. At 14 weeks' gestation… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Normal muscle

V Dubowitz, C. Sewry
  • 2007
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…