Abnormal ventral frontal response during performance of an affective go/no go task in patients with mania

@article{Elliott2004AbnormalVF,
  title={Abnormal ventral frontal response during performance of an affective go/no go task in patients with mania},
  author={Rebecca Elliott and Alan D. Ogilvie and Judy Sasha Rubinsztein and Gloria Calderon and Raymond J. Dolan and Barbara Jacquelyn Sahakian},
  journal={Biological Psychiatry},
  year={2004},
  volume={55},
  pages={1163-1170}
}
BACKGROUND Patients with mania show a behavioral bias toward positive information in an emotional go/no go task. This is the converse of the bias toward negative information seen in unipolar depression that we have recently related to the abnormal function of ventral and medial prefrontal cortices (PFCs). The aim of this study was to investigate the neuronal basis of the bias toward positive information in manic patients. METHODS During performance of an emotional go/no go task using… 
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Failure of de-activation in the medial frontal cortex in mania: evidence for default mode network dysfunction in the disorder
  • E. Pomarol-Clotet, N. Moro, +9 authors R. Salvador
  • Psychology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2012
TLDR
It is suggested that, in addition to reduced prefrontal activation, failure of de-activation is an important functional imaging abnormality in mania, and its location in the medial prefrontal cortex implies default mode network dysfunction in the disorder.
Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania
TLDR
Compared with healthy subjects, manic patients had a significantly reduced VLPFC regulation of amygdala response during the emotion labeling task, suggesting that reductions in inhibitory frontal activity in these patients may lead to an increased reactivity of the amygdala.
Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia
TLDR
Using functional magnetic resonance imaging, euthymic bipolar and demographically matched healthy control subjects were scanned while performing an affective task paradigm involving the matching and labeling of emotional facial expressions and results suggested that amygdala dysfunction may be a state-related abnormality in bipolar disorder, whereas vlPFC dysfunction may represent a trait- related abnormality of the illness.
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