Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.

@article{Omarova2012AbnormalVI,
  title={Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.},
  author={Saida Omarova and Casey D. Charvet and Rachel E. Reem and Natalia Mast and Wenchao Zheng and Suber S. Huang and Neal S Peachey and Irina A Pikuleva},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 8},
  pages={3012-23}
}
Several lines of evidence suggest a link between age-related macular degeneration and retinal cholesterol maintenance. Cytochrome P450 27A1 (CYP27A1) is a ubiquitously expressed mitochondrial sterol 27-hydroxylase that plays an important role in the metabolism of cholesterol and cholesterol-related compounds. We conducted a comprehensive ophthalmic evaluation of mice lacking CYP27A1. We found that the loss of CYP27A1 led to dysregulation of retinal cholesterol homeostasis, including unexpected… CONTINUE READING
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Features of the retinal environment which affect the activities and product profile of cholesterol - metabolizing cytochromes P 450 CYP 27 A 1 and CYP 11 A 1

  • GY Heo, I Bederman, N Mast, WL Liao, IV Turko, IA Pikuleva
  • Arch Biochem Biophys
  • 2012

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