Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.

  title={Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.},
  author={Saida Omarova and Casey D. Charvet and Rachel E. Reem and Natalia Mast and Wenchao Zheng and Suber S. Huang and Neal S Peachey and Irina A Pikuleva},
  journal={The Journal of clinical investigation},
  volume={122 8},
Several lines of evidence suggest a link between age-related macular degeneration and retinal cholesterol maintenance. Cytochrome P450 27A1 (CYP27A1) is a ubiquitously expressed mitochondrial sterol 27-hydroxylase that plays an important role in the metabolism of cholesterol and cholesterol-related compounds. We conducted a comprehensive ophthalmic evaluation of mice lacking CYP27A1. We found that the loss of CYP27A1 led to dysregulation of retinal cholesterol homeostasis, including unexpected… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
12 Citations
79 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 12 extracted citations


Publications referenced by this paper.
Showing 1-10 of 79 references

Features of the retinal environment which affect the activities and product profile of cholesterol - metabolizing cytochromes P 450 CYP 27 A 1 and CYP 11 A 1

  • GY Heo, I Bederman, N Mast, WL Liao, IV Turko, IA Pikuleva
  • Arch Biochem Biophys
  • 2012

Similar Papers

Loading similar papers…