Abnormal transsulfuration and glutathione metabolism in the micropig model of alcoholic liver disease.

@article{Villanueva2006AbnormalTA,
  title={Abnormal transsulfuration and glutathione metabolism in the micropig model of alcoholic liver disease.},
  author={Jesus A. Villanueva and Farah Esfandiari and Donna H. Wong and Iram Ahmad and Stepan Melnyk and S. Jill James and Charles H. Halsted},
  journal={Alcoholism, clinical and experimental research},
  year={2006},
  volume={30 7},
  pages={1262-70}
}
BACKGROUND Alcoholic liver disease is associated with abnormalities of methionine metabolic enzymes that may contribute to glutathione depletion. Previously, we found that feeding micropigs a combination of ethanol with a folate-deficient diet resulted in the greatest decreases in S-adenosylmethionine and glutathione and increases in liver S… CONTINUE READING