Abnormal transsulfuration and glutathione metabolism in the micropig model of alcoholic liver disease.

@article{Villanueva2006AbnormalTA,
  title={Abnormal transsulfuration and glutathione metabolism in the micropig model of alcoholic liver disease.},
  author={Jesus A. Villanueva and Farah Esfandiari and Donna H. Wong and Iram Raza Ahmad and Stepan Melnyk and Stephen J. James and Charles H. Halsted},
  journal={Alcoholism, clinical and experimental research},
  year={2006},
  volume={30 7},
  pages={
          1262-70
        }
}
  • Jesus A. Villanueva, Farah Esfandiari, +4 authors Charles H. Halsted
  • Published in
    Alcoholism, clinical and…
    2006
  • Psychology, Medicine
  • BACKGROUND Alcoholic liver disease is associated with abnormalities of methionine metabolic enzymes that may contribute to glutathione depletion. Previously, we found that feeding micropigs a combination of ethanol with a folate-deficient diet resulted in the greatest decreases in S-adenosylmethionine and glutathione and increases in liver S-adenosylhomocysteine and oxidized disulfide glutathione. METHODS To study the mechanisms of glutathione depletion, we analyzed the transcripts and… CONTINUE READING

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