Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies.

@article{Tang2012AbnormalTO,
  title={Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies.},
  author={Yijun Tang and Xixi Tian and Ruiwu Wang and Michael Fill and S R Wayne Chen},
  journal={Circulation research},
  year={2012},
  volume={110 7},
  pages={968-77}
}
RATIONALE Naturally occurring mutations in the cardiac ryanodine receptor (RyR2) have been associated with both cardiac arrhythmias and cardiomyopathies. It is clear that delayed afterdepolarization resulting from abnormal activation of sarcoplasmic reticulum Ca2+ release is the primary cause of RyR2-associated cardiac arrhythmias. However, the mechanism… CONTINUE READING