Abnormal synchrony of resting state networks in premanifest and symptomatic Huntington disease: the IMAGE-HD study.

@article{Poudel2014AbnormalSO,
  title={Abnormal synchrony of resting state networks in premanifest and symptomatic Huntington disease: the IMAGE-HD study.},
  author={Govinda R. Poudel and Gary F. Egan and Andrew C Churchyard and Phyllis Chua and Julie C. Stout and Nellie Georgiou-Karistianis},
  journal={Journal of psychiatry & neuroscience : JPN},
  year={2014},
  volume={39 2},
  pages={87-96}
}
BACKGROUND Functional neural impairments have been documented in people with symptomatic Huntington disease (symp-HD) and in premanifest gene carriers (pre-HD). This study aimed to characterize synchrony in resting state cerebral networks in both pre-HD and symp-HD populations and to determine its association with disease burden and neurocognitive functions. METHODS We acquired functional magnetic resonance imaging (fMRI) data from pre-HD, symp-HD and healthy control participants. The fMRI… CONTINUE READING
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