Abnormal synaptic protein expression and cell death in murine scrapie

  title={Abnormal synaptic protein expression and cell death in murine scrapie},
  author={S{\'i}lvia S{\'i}so and Berta Puig and Ruth Varea and Enric Vidal and Cristina Ac{\'i}n and Marco Prinz and Fabio Montrasio and J I Badiola and Adriano Aguzzi and Mart{\'i} Batlle Pumarola and Isidro Ferrer},
  journal={Acta Neuropathologica},
Reduced expression of synaptophysin p38, synaptic-associated protein of molecular weight 25,000 (SNAP-25), syntaxin-1, synapsin-1, and α- and β-synuclein, matching the distribution of spongiform degeneration, was found in the neurological phase of scrapie-infected mice. In addition, synaptophysin and SNAP-25 were accumulated in isolated neurons, mainly in the thalamus, midbrain and pons, and granular deposits of α- and β-synuclein were present in the neuropil of the same areas. No modifications… CONTINUE READING


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