Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.

@article{Bishop2008AbnormalSD,
  title={Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.},
  author={Tammie Bishop and Denis Gallagher and Alberto Pascual and Craig A Lygate and Joseph P. de Bono and Lynn G. Nicholls and Patricia Ortega-S{\'a}enz and Henrik Oster and Bhathiya Wijeyekoon and Andrew I Sutherland and Alexandra Grosfeld and Juli{\'a}n Aragon{\'e}s and Martin Schneider and Katie van Geyte and Dania Teixeira and Antonio D{\'i}ez-Juan and Jos{\'e} L{\'o}pez-Barneo and Keith M. Channon and Patrick Henry Maxwell and Christopher W Pugh and Alun M Davies and Peter Carmeliet and Peter J Ratcliffe},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 10},
  pages={3386-400}
}
Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the regulation of neuronal apoptosis. To better understand this function in vivo, we have created PHD3(-/-) mice and analyzed the neuronal phenotype. Reduced apoptosis in superior cervical ganglion (SCG) neurons cultured from PHD3(-/-) mice is associated with an increase in the number of cells in the SCG, as well as in the adrenal medulla and carotid body. Genetic analysis by… CONTINUE READING

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