Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.

  title={Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.},
  author={Tammie Bishop and Denis Gallagher and Alberto Pascual and Craig A Lygate and Joseph P. de Bono and Lynn G. Nicholls and Patricia Ortega-S{\'a}enz and Henrik Oster and Bhathiya Wijeyekoon and Andrew I Sutherland and Alexandra Grosfeld and Juli{\'a}n Aragon{\'e}s and Martin Schneider and Katie van Geyte and Dania Teixeira and Antonio D{\'i}ez-Juan and Jos{\'e} L{\'o}pez-Barneo and Keith M. Channon and Patrick Henry Maxwell and Christopher W Pugh and Alun M Davies and Peter Carmeliet and Peter J Ratcliffe},
  journal={Molecular and cellular biology},
  volume={28 10},
Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF) prolyl hydroxylase PHD3 in the regulation of neuronal apoptosis. To better understand this function in vivo, we have created PHD3(-/-) mice and analyzed the neuronal phenotype. Reduced apoptosis in superior cervical ganglion (SCG) neurons cultured from PHD3(-/-) mice is associated with an increase in the number of cells in the SCG, as well as in the adrenal medulla and carotid body. Genetic analysis by… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 83 extracted citations


Publications referenced by this paper.
Showing 1-10 of 44 references

Similar Papers

Loading similar papers…