Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors.

@article{Salvadori1994AbnormalST,
  title={Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors.},
  author={Silvia Salvadori and Bernd Gansbacher and A M Pizzimenti and Karen S. Zier},
  journal={Journal of immunology},
  year={1994},
  volume={153 11},
  pages={5176-82}
}
There is considerable evidence to demonstrate that immune function is abnormal in tumor-bearing mice, perhaps accounting, at least in part, for progressive tumor growth. In an attempt to generate an antitumor response, we used retroviral vectors to express IL-2 cDNA in CMS5, a murine fibrosarcoma. Mice inoculated with unmodified tumor cells suffered progressive tumor growth, whereas tumors secreting IL-2 were rejected or grew slowly. Animals bearing unmodified but not IL-2-secreting tumors also… CONTINUE READING

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