Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies

@article{Yarchoan2014AbnormalSP,
  title={Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer’s disease and tauopathies},
  author={Mark Yarchoan and Jon B. Toledo and Edward K. B. Lee and Zoe Arvanitakis and Hala Altaf Kazi and Li-ying Han and Natalia Louneva and Virginia M. Y. Lee and SangWon Kim and John Q. Trojanowski and Steven E Arnold},
  journal={Acta Neuropathologica},
  year={2014},
  volume={128},
  pages={679-689}
}
Neuronal insulin signaling abnormalities have been associated with Alzheimer’s disease (AD). However, the specificity of this association and its underlying mechanisms have been unclear. This study investigated the expression of abnormal serine phosphorylation of insulin receptor substrate 1 (IRS1) in 157 human brain autopsy cases that included AD, tauopathies, α-synucleinopathies, TDP-43 proteinopathies, and normal aging. IRS1-pS616, IRS1-pS312 and downstream target Akt-pS473 measures were… CONTINUE READING
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