Abnormal response of superior sinoatrial node to sympathetic stimulation is a characteristic finding in patients with atrial fibrillation and symptomatic bradycardia.

@article{Joung2011AbnormalRO,
  title={Abnormal response of superior sinoatrial node to sympathetic stimulation is a characteristic finding in patients with atrial fibrillation and symptomatic bradycardia.},
  author={Boyoung Joung and Hye Jin Hwang and Hui-Nam Pak and Moon-hyoung Lee and Changyu Shen and Shien-Fong Lin and Peng-Sheng Chen},
  journal={Circulation. Arrhythmia and electrophysiology},
  year={2011},
  volume={4 6},
  pages={799-807}
}
BACKGROUND We hypothesized that unresponsiveness of superior sinoatrial node (SAN) to sympathetic stimulation is strongly associated with the development of symptomatic bradycardia in patients with atrial fibrillation (AF). METHODS AND RESULTS We performed 3D endocardial mapping in healthy controls (group 1, n=10) and patients with AF without (group 2, n=57) or with (group 3, n=15) symptomatic bradycardia at baseline and during isoproterenol infusion. Corrected SAN recovery time was abnormal… CONTINUE READING
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