Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus.

  title={Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus.},
  author={Christian Meyer and Michael Stumvoll and Veena Nadkarni and Jean M. Dostou and Asimina Mitrakou and John E. Gerich},
  journal={The Journal of clinical investigation},
  volume={102 3},
Release of glucose by liver and kidney are both increased in diabetic animals. Although the overall release of glucose into the circulation is increased in humans with diabetes, excessive release of glucose by either their liver or kidney has not as yet been demonstrated. The present experiments were therefore undertaken to assess the relative contributions of hepatic and renal glucose release to the excessive glucose release found in type 2 diabetes. Using a combination of isotopic and balance… CONTINUE READING
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