Abnormal regulatory interactions of I148T-CFTR and the epithelial Na+ channel in Xenopus oocytes.

@article{Suaud2007AbnormalRI,
  title={Abnormal regulatory interactions of I148T-CFTR and the epithelial Na+ channel in Xenopus oocytes.},
  author={Laurence Suaud and Wusheng Yan and Ronald C Rubenstein},
  journal={American journal of physiology. Cell physiology},
  year={2007},
  volume={292 1},
  pages={
          C603-11
        }
}
The mechanisms underlying regulatory interactions of the cystic fibrosis transmembrane conductance regulator (CFTR) and the epithelial Na(+) channel (ENaC) in Xenopus oocytes are controversial. CFTR's first nucleotide binding domain (NBD-1) may be important in these interactions, because mutations within NBD-1 impair these functional interactions. We hypothesized that an abnormal CFTR containing a non-NBD-1 mutation and able to transport chloride would retain regulatory interactions with murine… CONTINUE READING
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