Abnormal regulatory and effector T cell function predispose to autoimmunity following xenogeneic thymic transplantation.

@article{Fudaba2008AbnormalRA,
  title={Abnormal regulatory and effector T cell function predispose to autoimmunity following xenogeneic thymic transplantation.},
  author={Yasuhiro Fudaba and Takashi Onoe and Meredith Chittenden and Akira Shimizu and Juanita M Shaffer and Roderick Bronson and Megan Sykes},
  journal={Journal of immunology},
  year={2008},
  volume={181 11},
  pages={7649-59}
}
Porcine thymus grafts support robust murine and human thymopoiesis, generating a diverse T cell repertoire that is deleted of donor and host-reactive cells, achieving specific xenograft tolerance. Positive selection is mediated exclusively by the xenogeneic thymic MHC. Although thymectomized, T cell-depleted normal mice usually remain healthy following xenogeneic thymic transplantation, thymus-grafted congenitally athymic mice frequently develop multiorgan autoimmunity. We investigated the… CONTINUE READING

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