Abnormal regulation of insulin-like growth factor binding proteins in adolescents with insulin-dependent diabetes.

@article{Batch1991AbnormalRO,
  title={Abnormal regulation of insulin-like growth factor binding proteins in adolescents with insulin-dependent diabetes.},
  author={Jennifer A. Batch and Robert C. Baxter and George Arthur Werther},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1991},
  volume={73 5},
  pages={964-8}
}
We have measured fasting 0800 h insulin-like growth factor binding proteins (IGFBP)-1 and IGFBP-3, in 52 diabetic adolescents and 74 puberty-matched control subjects with short stature and normal hormonal status. We have also measured overnight hourly profiles of IGFBP-1, glucose, free insulin, and GH in 12 of the diabetic adolescents. With advancing age and pubertal status, IGFBP-1 declined and IGFBP-3 increased significantly in the control, but not the diabetic group. Fasting IGFBP-1 levels… CONTINUE READING
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