Abnormal regional brain function in Parkinson's disease: truth or fiction?

@article{Ma2009AbnormalRB,
  title={Abnormal regional brain function in Parkinson's disease: truth or fiction?},
  author={Yilong Ma and Chengke Tang and James Ralph Moeller and David Eidelberg},
  journal={NeuroImage},
  year={2009},
  volume={45 2},
  pages={260-6}
}
Normalization of regional measurements by the global mean is commonly employed to minimize inter-subject variability in functional imaging studies. This practice is based on the assumption that global values do not substantially differ between patient and control groups. In this issue of NeuroImage, Borghammer and colleagues challenge the validity of this assumption. They focus on Parkinson's disease (PD) and use computer simulations to show that lower global values can produce spurious… CONTINUE READING