Abnormal prion protein is associated with changes of plasma membranes and endocytosis in bovine spongiform encephalopathy (BSE)-affected cattle brains.

@article{Ersdal2009AbnormalPP,
  title={Abnormal prion protein is associated with changes of plasma membranes and endocytosis in bovine spongiform encephalopathy (BSE)-affected cattle brains.},
  author={C Ersdal and Caroline M. Goodsir and Marion M Simmons and Gillian McGovern and M Haddad Jeffrey},
  journal={Neuropathology and applied neurobiology},
  year={2009},
  volume={35 3},
  pages={259-71}
}
AIMS Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal neurodegenerative diseases of man and animals characterized by vacuolation and gliosis of neuropil and the accumulation of abnormal isoforms of a host protein known as prion protein (PrP). It is widely assumed that the abnormal isoforms of PrP (PrP(d), disease-specific form of PrP) are the proximate cause of neurodegeneration. METHODS To determine the nature of subcellular changes and their association with PrP… CONTINUE READING