Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis.

  title={Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis.},
  author={Pierre-Emmanuel Rautou and Julie Bresson and Yannis Sainte-Marie and Anne-Cl{\'e}mence Vion and Val{\'e}rie Paradis and Jean-Marie Renard and C{\'e}cile Devue and Christophe Heymes and Philippe Lett{\'e}ron and L Elkrief and Didier Lebrec and Dominique Charles Valla and Alain Tedgui and Richard Moreau and Chantal M Boulanger},
  volume={143 1},
BACKGROUND & AIMS Circulating membrane-shed microparticles (MPs) participate in regulation of vascular tone. We investigated the cellular origins of MPs in plasma from patients with cirrhosis and assessed the contribution of MPs to arterial vasodilation, a mechanism that contributes to portal hypertension. METHODS We analyzed MPs from blood samples of 91 patients with cirrhosis and 30 healthy individuals (controls) using flow cytometry; their effects on the vascular response to… CONTINUE READING
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