Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice

@article{Flatt1981AbnormalPG,
  title={Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice},
  author={Peter Raymond Flatt and Clifford J Bailey},
  journal={Diabetologia},
  year={1981},
  volume={20},
  pages={573-577}
}
To investigate the effect of the ob gene in the heterozygous condition, plasma glucose and insulin responses of adult heterozygous lean (ob/+) mice were compared with mice of the homozygous lean (+/+) and homozygous obese (ob/ob) genotypes. The ob/+ mice consumed 24% more food than +/+ mice although body weights were similar. Plasma glucose and insulin concentrations were respectively 16% and 176% higher in ob/+ mice than +/+ mice in the freely fed state, and 44% and 88% higher during glucose… CONTINUE READING
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