Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice

  title={Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice},
  author={Peter Raymond Flatt and Clifford J Bailey},
To investigate the effect of the ob gene in the heterozygous condition, plasma glucose and insulin responses of adult heterozygous lean (ob/+) mice were compared with mice of the homozygous lean (+/+) and homozygous obese (ob/ob) genotypes. The ob/+ mice consumed 24% more food than +/+ mice although body weights were similar. Plasma glucose and insulin concentrations were respectively 16% and 176% higher in ob/+ mice than +/+ mice in the freely fed state, and 44% and 88% higher during glucose… CONTINUE READING
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Importance of the enteroinsular axis for the insulin secretory response to glucose in obese hyperglycaemic ( ob / ob ) mice

  • PR Flatt, SK Swanston-Flatt, CJ Bailey
  • Biochem Soc Trans
  • 1979

The development of obesity , hyperinsulinaemia and hyperglycaemia in ob / ob mice

  • EdwardsonJA, Hough CAM
  • Metabolism
  • 1976

Gas - trointestinal apudosis in obese hyperglycaemic mice

  • PearseAGE PolakJM, GrimeliusL, V Marks
  • Virchows Arch [ Pathol Anat ]
  • 1975

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