Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy.

@article{Cha2001AbnormalOI,
  title={Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy.},
  author={Seunghee Ro Cha and S C van Blockland and Marjan A. Versnel and Françoise Homo-Delarche and Hiroshi Nagashima and Jason Brayer and Ammon Broughton Peck and Michael G. Humphreys-Beher},
  journal={Experimental and clinical immunogenetics},
  year={2001},
  volume={18 3},
  pages={143-60}
}
OBJECTIVES Salivary gland organogenesis was evaluated in NOD mice, an animal model for autoimmune exocrinopathy, to determine when disease onset is first present in the target tissues. METHODS Submandibular glands were removed for histological, immunohistochemical and biochemical evaluation from neonatal NOD and congenic strains as well as healthy control C57BL/6 mice. RESULTS Histomorphological analyses of neonatal submandibular glands, the primary target for autoimmune exocrinopathy at 1… CONTINUE READING
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