Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative Golgi study.

@article{Takashima1981AbnormalND,
  title={Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative Golgi study.},
  author={Sachio Takashima and Laurence Edward Becker and Dawna La-Vina Duncan Armstrong and Felix H W Chan},
  journal={Brain research},
  year={1981},
  volume={225 1},
  pages={1-21}
}
The developmental morphology of visual cortical neurons (their numbers, dendritic arborization and numbers of spines) in 14 fetuses and infants with Down's syndrome were studied and compared with that of neurologically normal, age-matched controls. Fetuses with Trisomy 21 showed the same neuronal morphology and spine counts as control fetuses. However, the newborns and older infants with Down's syndrome showed shorter basilar dendrites and decreased numbers of spines with altered morphology and… CONTINUE READING