Abnormal neural oscillations and synchrony in schizophrenia
@article{Uhlhaas2010AbnormalNO, title={Abnormal neural oscillations and synchrony in schizophrenia}, author={Peter J. Uhlhaas and Wolf Singer}, journal={Nature Reviews Neuroscience}, year={2010}, volume={11}, pages={100-113} }
Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma…
1,709 Citations
High-Frequency Oscillations in Schizophrenia
- PsychologyClinical EEG and neuroscience
- 2011
The focus is on the role of high-frequency oscillations for cortical computations through establishing correlations between the modulation of oscillations in the β/γ frequency range and specific cognitive processes during normal brain functioning and in schizophrenia.
Gamma Oscillation in Schizophrenia
- Psychology, MedicinePsychiatry investigation
- 2011
An overview of the neural basis of gamma oscillations and the abnormalities in the GABAergic interneuronal system thought to be responsible for gamma-range deficits in schizophrenia is presented.
Brain functional connectivity and the pathophysiology of schizophrenia.
- PsychologyPsychiatrike = Psychiatriki
- 2014
Phase synchronization analyses performed on EEG segments during the experience of TBs showed that synchrony values exhibited a long-range common mode of coupling (grouped behavior) among the left temporal area and the remaining central and frontal brain areas, and the introduction of synchrony entropy analysis applied on the cumulative synchrony distribution showed that TB states were characterized by an explicit preference of the system to be functioned at low values of synchronY.
Impairement of Gamma Oscillation in Patients with Schizophrenia
- Psychology
- 2011
This work has shown that the fast-spiking cells that contain the calcium-binding protein parvalbumin appear to play a particularly critical role in the generation of synchronized gamma activity, and it is anticipated that futher roles of gamma band could be come out someday.
High-frequency oscillations and the neurobiology of schizophrenia
- PsychologyDialogues in clinical neuroscience
- 2013
The current evidence for impaired beta/gamma-band oscillations and their involvement in cognitive functions and certain symptoms of the disorder is reviewed and critical issues for future research in this area are identified.
Oscillations and Neuronal Dynamics in Schizophrenia: The Search for Basic Symptoms and Translational Opportunities
- Psychology, MedicineBiological Psychiatry
- 2015
Neural synchrony and the development of cortical networks
- Psychology, BiologyTrends in Cognitive Sciences
- 2010
Alterations of Cortical GABA Neurons and Network Oscillations in Schizophrenia
- Psychology, BiologyCurrent psychiatry reports
- 2010
Recent studies indicate that inhibition from parvalbumin-positive GABA neurons is necessary to produce γ oscillations in cortical circuits, and studies using novel, noninvasive approaches directly assessing potential relations between alterations in GABA, oscillations, and cognitive function in schizophrenia are described.
Impaired GABAergic Neurotransmission in Schizophrenia Underlies Impairments in Cortical Gamma Band Oscillations
- Psychology, MedicineCurrent Psychiatry Reports
- 2013
Current understanding of the Sz related cortical circuit dysfunction is reviewed with a particular focus on the role of fast spiking parvalbumin interneurons in both normal cortical circuit activity and in NMDA receptor hypofunction models of the schizophrenia disease state.
Current findings and perspectives on aberrant neural oscillations in schizophrenia
- PsychologyPsychiatry and clinical neurosciences
- 2021
The evidence for aberrant rhythmic activity in schizophrenia is assessed through evaluating studies that have utilized Electro/Magnetoencephalography to examine neural oscillations during sensory and cognitive tasks as well as during resting‐state measurements.
References
SHOWING 1-10 OF 214 REFERENCES
Abnormal Neural Synchrony in Schizophrenia
- Psychology, MedicineThe Journal of Neuroscience
- 2003
Findings support the hypothesis that schizophrenia is associated with impaired neural circuitry demonstrated as a failure of gamma band synchronization, especially in the 40 Hz range.
Neural Synchrony in Brain Disorders: Relevance for Cognitive Dysfunctions and Pathophysiology
- Psychology, BiologyNeuron
- 2006
Neural synchrony indexes disordered perception and cognition in schizophrenia.
- Psychology, MedicineProceedings of the National Academy of Sciences of the United States of America
- 2004
It is reported that, in both healthy controls and schizophrenia patients, visual Gestalt stimuli elicit a gamma-band oscillation that is phase-locked to reaction time and hence may reflect processes leading to conscious perception of the stimuli, but the frequency of this oscillation is lower in schizophrenics than in healthy individuals.
Dysfunctional Long-Range Coordination of Neural Activity during Gestalt Perception in Schizophrenia
- Psychology, MedicineThe Journal of Neuroscience
- 2006
It is suggested that schizophrenia patients are impaired in the long-range synchronization of neural responses, which may reflect a core deficit in the coordination of neural activity and underlie the specific cognitive dysfunctions associated with the disorder.
Schizophrenia and the disconnection hypothesis
- PsychologyActa psychiatrica Scandinavica. Supplementum
- 1999
The proposed pathophysiology of schizophrenia is expressed at the level of modulation of associative changes in synaptic efficacy, specifically the modulation of plasticity in those brain systems that are responsible for learning, memory and emotion.
Gamma Band Oscillations Reveal Neural Network Cortical Coherence Dysfunction in Schizophrenia Patients
- Psychology, MedicineBiological Psychiatry
- 2006
Cortical Oscillatory Activity Is Critical for Working Memory as Revealed by Deficits in Early-Onset Schizophrenia
- Psychology, MedicineThe Journal of Neuroscience
- 2009
The findings suggest that the WM deficit in schizophrenia is associated with impaired oscillatory activity during all phases of the task and that the cortical storage system reaches its capacity limit at lower loads.
Cortical inhibitory neurons and schizophrenia
- Psychology, BiologyNature Reviews Neuroscience
- 2005
Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
Cortical gamma generators suggest abnormal auditory circuitry in early-onset psychosis.
- PsychologyCerebral cortex
- 2008
Patients with psychosis exhibited significantly reduced overall gamma power relative to controls, and showed a reduced ear-of-stimulation effect indicating that ipsi- versus contralateral presentation had less impact on hemispheric power, potentially suggesting that local circuit integrity is at least partially compromised early in the disease process.
The reduced neuropil hypothesis: a circuit based model of schizophrenia
- Psychology, BiologyBiological Psychiatry
- 1999