Abnormal neural oscillations and synchrony in schizophrenia

@article{Uhlhaas2010AbnormalNO,
  title={Abnormal neural oscillations and synchrony in schizophrenia},
  author={Peter J. Uhlhaas and Wolf Singer},
  journal={Nature Reviews Neuroscience},
  year={2010},
  volume={11},
  pages={100-113}
}
Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma… 
High-Frequency Oscillations in Schizophrenia
  • P. Uhlhaas
  • Psychology
    Clinical EEG and neuroscience
  • 2011
TLDR
The focus is on the role of high-frequency oscillations for cortical computations through establishing correlations between the modulation of oscillations in the β/γ frequency range and specific cognitive processes during normal brain functioning and in schizophrenia.
Gamma Oscillation in Schizophrenia
TLDR
An overview of the neural basis of gamma oscillations and the abnormalities in the GABAergic interneuronal system thought to be responsible for gamma-range deficits in schizophrenia is presented.
Brain functional connectivity and the pathophysiology of schizophrenia.
TLDR
Phase synchronization analyses performed on EEG segments during the experience of TBs showed that synchrony values exhibited a long-range common mode of coupling (grouped behavior) among the left temporal area and the remaining central and frontal brain areas, and the introduction of synchrony entropy analysis applied on the cumulative synchrony distribution showed that TB states were characterized by an explicit preference of the system to be functioned at low values of synchronY.
Impairement of Gamma Oscillation in Patients with Schizophrenia
TLDR
This work has shown that the fast-spiking cells that contain the calcium-binding protein parvalbumin appear to play a particularly critical role in the generation of synchronized gamma activity, and it is anticipated that futher roles of gamma band could be come out someday.
High-frequency oscillations and the neurobiology of schizophrenia
TLDR
The current evidence for impaired beta/gamma-band oscillations and their involvement in cognitive functions and certain symptoms of the disorder is reviewed and critical issues for future research in this area are identified.
Alterations of Cortical GABA Neurons and Network Oscillations in Schizophrenia
TLDR
Recent studies indicate that inhibition from parvalbumin-positive GABA neurons is necessary to produce γ oscillations in cortical circuits, and studies using novel, noninvasive approaches directly assessing potential relations between alterations in GABA, oscillations, and cognitive function in schizophrenia are described.
Impaired GABAergic Neurotransmission in Schizophrenia Underlies Impairments in Cortical Gamma Band Oscillations
TLDR
Current understanding of the Sz related cortical circuit dysfunction is reviewed with a particular focus on the role of fast spiking parvalbumin interneurons in both normal cortical circuit activity and in NMDA receptor hypofunction models of the schizophrenia disease state.
Current findings and perspectives on aberrant neural oscillations in schizophrenia
TLDR
The evidence for aberrant rhythmic activity in schizophrenia is assessed through evaluating studies that have utilized Electro/Magnetoencephalography to examine neural oscillations during sensory and cognitive tasks as well as during resting‐state measurements.
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