Abnormal neocortical development in mice lacking cGMP-dependent protein kinase I.

@article{Demyanenko2005AbnormalND,
  title={Abnormal neocortical development in mice lacking cGMP-dependent protein kinase I.},
  author={Galina P. Demyanenko and Ari I Halberstadt and Katherine B. Pryzwansky and Claudia Werner and Franz Hofmann and Patricia F. Maness},
  journal={Brain research. Developmental brain research},
  year={2005},
  volume={160 1},
  pages={1-8}
}
Cyclic GMP-dependent protein kinase type I (cGKI) is a key signaling intermediate important for synaptic potentiation in the hippocampus and cerebellum, but its expression and function in cortical development have not been elucidated. The expression of cGKI in the developing mouse neocortex was evaluated by immunofluorescence labeling, and effect of cGKI deletion on cortical development was studied in adult cGKI knockout mice. cGKI was expressed at highest levels at embryonic stages in young… CONTINUE READING
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