Abnormal mucosal extracellular matrix deposition is associated with increased TGF-beta receptor-expressing mesenchymal cells in a mouse model of colitis.

@article{Whiting2003AbnormalME,
  title={Abnormal mucosal extracellular matrix deposition is associated with increased TGF-beta receptor-expressing mesenchymal cells in a mouse model of colitis.},
  author={Christine Vivienne Whiting and John Tarlton and Michael L Bailey and Clare L Morgan and Paul W. Bland},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2003},
  volume={51 9},
  pages={1177-89}
}
Transforming growth factor-beta (TGF-beta) depresses mucosal inflammation and upregulates extracellular matrix (ECM) deposition. We analyzed TGF-beta receptors RI and RII as well as ECM components using the CD4(+) T-cell-transplanted SCID mouse model of colitis. The principal change in colitis was an increased proportion of TGF-beta RII(+) mucosal mesenchymal cells, predominantly alpha-smooth muscle actin (SMA)(+) myofibroblasts, co-expressing vimentin and basement membrane proteins, but not… CONTINUE READING