Abnormal mitosis triggers p53-dependent cell cycle arrest in human tetraploid cells

@article{Kuffer2013AbnormalMT,
  title={Abnormal mitosis triggers p53-dependent cell cycle arrest in human tetraploid cells},
  author={Christian Kuffer and Anastasia Yurievna Kuznetsova and Zuzana Storchov{\'a}},
  journal={Chromosoma},
  year={2013},
  volume={122},
  pages={305-318}
}
Erroneously arising tetraploid mammalian cells are chromosomally instable and may facilitate cell transformation. An increasing body of evidence shows that the propagation of mammalian tetraploid cells is limited by a p53-dependent arrest. The trigger of this arrest has not been identified so far. Here we show by live cell imaging of tetraploid cells generated by an induced cytokinesis failure that most tetraploids arrest and die in a p53-dependent manner after the first tetraploid mitosis… CONTINUE READING

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