Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer

@inproceedings{Zhao2013AbnormalMO,
  title={Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer},
  author={Yangxing Zhao and Huafu Zhou and Kelong Ma and Jingfeng Sun and Xu Feng and Junfeng Geng and Jun Gu and Wei Wang and Hongyu Zhang and Yinghua He and Shicheng Guo and Xiaoyu Zhou and Jian Yu and Qiang Lin},
  booktitle={Oncology letters},
  year={2013}
}
To identify novel abnormally methylated genes in early stage non-small cell lung cancer (NSCLC), we analyzed the methylation status of 13 genes (ALX1, BCL2, FOXL2, HPP1, MYF6, OC2, PDGFRA, PHOX2A, PITX2, RARB, SIX6, SMPD3 and SOX1) in cancer tissues from 101 cases of stage I NSCLC patients and lung tissues from 30 cases of non-cancerous lung disease controls, using methylation-specific PCR (MSP). The methylation frequencies (29.70-64.36%) of 7 genes (MYF6, SIX6, SOX1, RARB, BCL2, PHOX2A and… CONTINUE READING
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