Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia.

@article{Marques2008AbnormalMO,
  title={Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia.},
  author={C Joana Marques and Paula Souza Teixeira da Costa and Bruno Vaz and Filipa Abreu Gomes de Carvalho and S Fernandes and Alberto Barros and M{\'a}rio Sousa},
  journal={Molecular human reproduction},
  year={2008},
  volume={14 2},
  pages={67-74}
}
Genomic imprinting marks in the male germ line are already established in the adult germinal stem cell population. We studied the methylation patterns of H19 and MEST imprinted genes in sperm of control and oligozoospermic patients, by bisulphite genomic sequencing. We here report that 7 out of 15 (46.7%) patients with a sperm count below 10 x 10(6)/ml display defective methylation of H19 and/or MEST imprinted genes. In these cases, hypomethylation was observed in 5.54% (1.2-8.3%) and complete… CONTINUE READING
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