Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice.

@article{Miettinen2001AbnormalLM,
  title={Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice.},
  author={Helena E. Miettinen and Helen Beryl Rayburn and Monty Krieger},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={108 11},
  pages={
          1717-22
        }
}
Mammalian female fertility depends on complex interactions between the ovary and the extraovarian environment (e.g., the hypothalamic-hypophyseal ovarian axis). The role of plasma lipoproteins in fertility was examined using HDL-receptor SR-BI knockout (KO) mice. SR-BI KO females have abnormal HDLs, ovulate dysfunctional oocytes, and are infertile. Fertility was restored when the structure and/or quantity of abnormal HDL was altered by inactivating the apoAI gene or administering the… CONTINUE READING

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References

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SHOWING 1-10 OF 47 REFERENCES

Role of the scavenger receptor class B type I ( SR - BI ) in a - tocopherol metabolism in mice

  • A Templeton
  • 2001

High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP - binding cassette transporter - 1

  • T. A. Christiansen-Weber
  • Proc . Natl . Acad . Sci . USA .
  • 2000

Infertility and the establishment of pregnancy - overview

  • K. K. Hansen, R. H. Knopp, M. R. Soules
  • British Med . Bull .
  • 2000

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