Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure.

@article{Morgan1990AbnormalIC,
  title={Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure.},
  author={James Plunkett Morgan and R E Erny and Paul D. Allen and William F Grossman and Judith K. Gwathmey},
  journal={Circulation},
  year={1990},
  volume={81 2 Suppl},
  pages={III21-32}
}
Intracellular Ca2+ release and reuptake are necessary for normal contraction and relaxation of the human heart. Intracellular Ca2+ transients were recorded with aequorin during isometric contraction of myocardium from patients with end-stage heart failure. In contrast to controls, contractions and Ca2+ transients of muscles from failing hearts were markedly prolonged, and the Ca2+ transients exhibited two distinct components. Muscles from the failing hearts showed a diminished capacity to… CONTINUE READING

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