Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat

@article{stenson1993AbnormalIS,
  title={Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat},
  author={C. -G. {\"O}stenson and Akhtar Khan and Samy M Abdel-Halim and Amel Guenifi and Koji A. O. Suzuki and Yasuo Goto and Suad Efend{\'i}c},
  journal={Diabetologia},
  year={1993},
  volume={36},
  pages={3-8}
}
Insulin secretion and islet glucose metabolism were compared in pancreatic islets isolated from GK/Wistar (GK) rats with spontaneous Type 2 (non-insulin-dependent) diabetes mellitus and control Wistar rats. Islet insulin content was 24.5±3.1 μU/ng islet DNA in GK rats and 28.8±2.5 μU/ng islet DNA in control rats, with a mean (±SEM) islet DNA content of 17.3±1.7 and 26.5±3.4 ng (p < 0.05), respectively. Basal insulin secretion at 3.3 mmol/l glucose was 0.19±0.03 μ · ng islet DNA−1· h−1 in GK rat… CONTINUE READING

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