Abnormal increase in the expression level of proliferating cell nuclear antigen (PCNA) in the liver and hepatic injury in rats with dietary cobalamin deficiency.

@article{Nakao2006AbnormalII,
  title={Abnormal increase in the expression level of proliferating cell nuclear antigen (PCNA) in the liver and hepatic injury in rats with dietary cobalamin deficiency.},
  author={Motoyuki Nakao and Nozomi Kono and Satoko Adachi and Shuhei Ebara and Tetsuya Adachi and Takumi Miura and Ryoichi Yamaji and Haruyuki Inui and Yoshihisa Nakano},
  journal={Journal of nutritional science and vitaminology},
  year={2006},
  volume={52 3},
  pages={
          168-73
        }
}
Dietary cobalamin (Cbl; vitamin B12) deficiency resulted in severe growth retardation in rats, and body weight in the Cbl-deficient rats at 20 wk of age was significantly lower compared with the age-matched Cbl-sufficient control rats. In contrast, liver weight, when normalized to body weight, was greater in the Cbl-deficient rats than in the controls (p<0.05). The expression level of proliferating cell nuclear antigen (PCNA), a marker for cell proliferation, in the liver was significantly… CONTINUE READING

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