Abnormal imitation‐related cortical activation sequences in Asperger's syndrome

@article{Nishitani2004AbnormalIC,
  title={Abnormal imitation‐related cortical activation sequences in Asperger's syndrome},
  author={Nobuyuki Nishitani and Sari Avikainen and Riitta Hari},
  journal={Annals of Neurology},
  year={2004},
  volume={55}
}
Subjects with Asperger's syndrome (AS) are impaired in social interaction and imitation, but the underlying brain mechanisms are poorly understood. Because the mirror‐neuron system (MNS) that matches observed and executed actions has been suggested to play an important role in imitation and in reading of other people's intentions, we assessed MNS functions in 8 adult AS subjects and in 10 healthy control subjects during imitation of still pictures of lip forms. In the control subjects, cortical… Expand
Neural mechanisms of imitation and ‘mirror neuron’ functioning in autistic spectrum disorder
TLDR
Overall, it is suggested that ASD is associated with altered patterns of brain activity during imitation, which could stem from poor integration between areas serving visual, motor, proprioceptive and emotional functions. Expand
Lateralization of the Human Mirror Neuron System
TLDR
The data indicate that visual and motor components of the human mirror system are not left-lateralized, and the left hemisphere superiority for language must be have been favored by other types of language precursors, perhaps auditory or multimodal action representations. Expand
MEG premotor abnormalities in children with Asperger's syndrome: Determinants of social behavior?
Children with Asperger's syndrome show deficits in social functioning while their intellectual and language development is intact suggesting a specific dysfunction in mechanisms mediating socialExpand
Right hemisphere contributions to imitation tasks
TLDR
Activity patterns suggest that the latter areas mediate the observed behavioural advantage of biological movements and indicate a predominant contribution of the right temporo‐frontal hemisphere to action observation–execution matching processes in intransitive movements, which has not been reported previously. Expand
The Action Imitation network and motor imitation in children and adolescents with autism
TLDR
The findings of this study support the role of AIN in imitation and a potential difference in the recruitment of this network in ASD children and adolescents with ASD during a motor imitation task. Expand
Dissociation of mirroring and mentalising systems in autism
TLDR
It is suggested that parietal mirror regions function normally in autism, while differences in action understanding could be due to abnormal function of cingulate, fusiform and medial prefrontal regions. Expand
Reactivity of the human primary motor cortex during observation of action
“Mirror neurons” are visuomotor neurons which are activated both when the individual is observing and performing an action. These cells were originally discovered in the ventral premotor cortex (areaExpand
Intact imitation of emotional facial actions in autism spectrum conditions
TLDR
It is suggested that previous apparent demonstrations of impairments to the MNS in ASC may be driven by a lack of visual attention to the stimuli or motor sequencing impairments, and therefore that there is, in fact, no MNS impairment in ASC. Expand
Brain stimulation over Broca’s area differentially modulates naming skills in neurotypical adults and individuals with Asperger’s syndrome
TLDR
The hypothesis that, in subjects with Asperger's syndrome (ASP), the dynamics of language‐related regions might be abnormal, so that repetitive transcranial magnetic stimulation (rTMS) over Broca’s area leads to differential behavioral effects as seen in neurotypical controls is supported. Expand
Movement interference in autism-spectrum disorder
TLDR
Results are interpreted as evidence that the ASD participant group either rely to a greater extent on the goal-directed imitation pathway, supporting claims that they have a specific deficit of the non-goal-directed imitate pathway, or exhibit reduced visuomotor integration. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 41 REFERENCES
Viewing Lip Forms Cortical Dynamics
TLDR
It is demonstrated that still pictures, only implying motion, activate the human MNS in a well-defined temporal order. Expand
Imitation, mirror neurons and autism
TLDR
It is suggested that in order for sophisticated cortical neuronal systems have evolved in which MNs function as key elements, early developmental failures of MN systems are likely to result in a consequent cascade of developmental impairments characterised by the clinical syndrome of autism. Expand
Normal movement reading in Asperger subjects.
TLDR
In both groups viewing hand actions modified the neuromagnetic approximately 20 Hz oscillatory activity in the primary motor cortex to the same extent, impaired mindreading and imitation skills found in AS and autism do not seem to result from dysfunction of the motor cortex part of the action execution/observation system. Expand
Temporal dynamics of cortical representation for action.
  • N. Nishitani, R. Hari
  • Psychology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2000
TLDR
The results suggest that the left BA44 is the orchestrator of the human "mirror neuron system" and is strongly involved in action imitation, and probably contributes to the understanding of actions made by others. Expand
Impaired Mirror-Image Imitation in Asperger and High-Functioning Autistic Subjects
TLDR
It is argued that, based on an error analysis of a behavioral imitation task, adult Asperger and high-functioning autistic subjects suffer from an intriguing deficit of imitation: they lack the natural preference for imitation in a mirror-image fashion. Expand
Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes.
TLDR
A physiological cause for the mentalizing dysfunction in autism is suggested: a bottleneck in the interaction between higher order and lower order perceptual processes. Expand
Medial Prefrontal and Subcortical Mechanisms Underlying the Acquisition of Motor and Cognitive Action Sequences in Humans
TLDR
The results show that beyond the execution of motor acts, the AMPC is selectively engaged in computing the relevance of cognitive goals that subjects intend to achieve, indicating that the fronto-striatal circuit, including the ventral striatum and AMPC, subserves hierarchically distinct evaluative processes mediating the human ability to build behavioral plans. Expand
‘Theory of mind’ in the brain. Evidence from a PET scan study of Asperger syndrome
TLDR
Five patients with Asperger syndrome with mild variant of autism with normal intellectual functioning were studied, and no task-related activity was found in this region of left medial prefrontal cortex, but normal activity was observed in immediately adjacent areas. Expand
Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas
TLDR
There was greater activity during imitation, compared with observation of emotions, in premotor areas including the inferior frontal cortex, as well as in the superior temporal cortex, insula, and amygdala, which may be a critical relay from action representation to emotion. Expand
Abnormal asymmetry in language association cortex in autism
TLDR
In boys with autism, language and social/face processing–related regions displayed abnormal asymmetry, and these structural abnormalities may relate tolanguage and social disturbances observed in autism. Expand
...
1
2
3
4
5
...