Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta- mice.

@article{Cho1998AbnormalHS,
  title={Abnormal hippocampal spatial representations in alphaCaMKIIT286A and CREBalphaDelta- mice.},
  author={Yoon Hea Cho and K Peter Giese and Heikki Tanila and Alcino J. Silva and Howard Eichenbaum},
  journal={Science},
  year={1998},
  volume={279 5352},
  pages={867-9}
}
Hippocampal "place cells" fire selectively when an animal is in a specific location. The fine-tuning and stability of place cell firing was compared in two types of mutant mice with different long-term potentiation (LTP) and place learning impairments. Place cells from both mutants showed decreased spatial selectivity. Place cell stability was also deficient in both mutants and, consistent with the severities in their LTP and spatial learning deficits, was more affected in mice with a point… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

Similar Papers

Loading similar papers…