Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation.

  title={Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation.},
  author={Bonnie J. Nagel and Shawna L. Palmer and Wilburn E. Reddick and John O. Glass and Kathleen J. Helton and Shengjie Wu and Xiaoping P Xiong and Larry E. Kun and Amar Gajjar and Raymond K. Mulhern},
  journal={AJNR. American journal of neuroradiology},
  volume={25 9},
BACKGROUND AND PURPOSE Children with medulloblastoma demonstrate post-treatment neurocognitive deficits in a number of areas, including memory performance. However, there is no definitive understanding of the neuropathology underlying these functional deficits. Previous literature has reported that hippocampal integrity is crucial to the acquisition of new episodic memories. Therefore, we hypothesized that longitudinal hippocampal volume measurements are abnormal in patients with… CONTINUE READING


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