Abnormal hemoglobins with high oxygen affinity and erythrocytosis.

  title={Abnormal hemoglobins with high oxygen affinity and erythrocytosis.},
  author={Henri Wajcman and Fr{\'e}d{\'e}ric Galact{\'e}ros},
  journal={Hematology and cell therapy},
  volume={38 4},
More than 200 hemoglobin variants with high oxygen affinity have been reported since 1966. In about one third of these, the increase in oxygen affinity is responsible for a compensatory erythrocytosis. The degree of erythrocytosis depends primarily upon the molecular defect of the hemoglobin molecule. Measurement of the oxygen binding properties of the blood (or of the stripped lysate) is a convenient test both for the diagnosis of these variants and for evaluation of their severity. In the… CONTINUE READING
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