Abnormal growth plate function in pigs carrying a dominant mutation in type X collagen

@article{Nielsen2000AbnormalGP,
  title={Abnormal growth plate function in pigs carrying a dominant mutation in type X collagen},
  author={V. Nielsen and C. Bendixen and J. Arnbjerg and C. S{\o}rensen and H. Jensen and N. Shukri and B. Thomsen},
  journal={Mammalian Genome},
  year={2000},
  volume={11},
  pages={1087-1092}
}
  • V. Nielsen, C. Bendixen, +4 authors B. Thomsen
  • Published 2000
  • Biology, Medicine
  • Mammalian Genome
  • Abstract. [...] Key Result Consistent with the clinical phenotype of SMCD patients, radiological and histological examination of the dwarf pigs revealed metaphyseal chondrodysplasia in the long bones. Yeast-based, two-hybrid protein interaction studies and in vitro assembly experiments demonstrated that the amino acid substitution interfered with the ability of the mutated collagen molecules to engage in trimerization. This work establishes that the chondrodysplastic dwarf pigs by genetic, biochemical…Expand Abstract
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