Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients.

@article{Jansen2004AbnormalGE,
  title={Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients.},
  author={E C L Jansen and Joop S E Laven and Henri B R Dommerholt and Jan Polman and Cindy van Rijt and Caroline van den Hurk and Jolanda Westland and Sietse Mosselman and Bart C. J. M. Fauser},
  journal={Molecular endocrinology},
  year={2004},
  volume={18 12},
  pages={3050-63}
}
Polycystic ovary syndrome (PCOS) represents the most common cause of anovulatory infertility and affects 5-10% of women of reproductive age. The etiology of PCOS is still unknown. The current study is the first to describe consistent differences in gene expression profiles in human ovaries comparing PCOS patients vs. healthy normoovulatory individuals. The microarray analysis of PCOS vs. normal ovaries identifies dysregulated expression of genes encoding components of several biological… CONTINUE READING
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