Abnormal frequencies of alleles in polymorphic markers of the 17q21 region is associated with breast cancer.

@article{Silva1999AbnormalFO,
  title={Abnormal frequencies of alleles in polymorphic markers of the 17q21 region is associated with breast cancer.},
  author={Jos{\'e} Mar{\'i}a Silva and Jos{\'e} Miguel Garc{\'i}a and Roc{\'i}o Gonz{\'a}lez and Gemma Dom{\'i}nguez and Eugenia Jare{\~n}o and Jos{\'e} Palacios and Fatima Navarro and M Provencia and Pilar Espa{\~n}a and F{\'e}lix Bonilla},
  journal={Cancer letters},
  year={1999},
  volume={138 1-2},
  pages={209-15}
}
This study was carried out to evaluate the frequencies of alleles of four polymorphic markers in the 17q21 region in breast cancer patients, and their relation to seven pathological parameters. One hundred and sixty-four patients with breast cancer and 102 controls were analyzed. D17S856, D17S855, D17S1323 and D17S1327 polymorphic markers were studied, and used to investigate loss of heterozygosity in this region. The frequencies of alleles at marker D17S856 differed significantly in breast… CONTINUE READING