Abnormal first trimester serum interleukin 18 levels are associated with a poor outcome in women with a history of recurrent miscarriage.

@article{Wilson2004AbnormalFT,
  title={Abnormal first trimester serum interleukin 18 levels are associated with a poor outcome in women with a history of recurrent miscarriage.},
  author={Rhoda Wilson and Judith Moor and Carol Jenkins and Helen Miller and James J. Walker and Marjorie A McLean and J Norman and Iain B. Mcinnes},
  journal={American journal of reproductive immunology},
  year={2004},
  volume={51 2},
  pages={156-9}
}
PROBLEM How the maternal immune system adapts to tolerate the fetus is not fully understood, but a successful pregnancy is associated with the production of Th2-type cytokines and miscarriage is associated with the production of Th1-type cytokines. METHOD OF STUDY Levels of interferon (IFN)-gamma, interleukin (IL)-4, IL-12 and IL-18 were measured in serum from 205 pregnant women of whom 115 pregnant women had a history of recurrent miscarriage. RESULTS Compared with healthy pregnant women… CONTINUE READING

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