Abnormal fibrin clot architecture in nephrotic patients is related to hypofibrinolysis: influence of plasma biochemical modifications: a possible mechanism for the high thrombotic tendency?

@article{Colle1999AbnormalFC,
  title={Abnormal fibrin clot architecture in nephrotic patients is related to hypofibrinolysis: influence of plasma biochemical modifications: a possible mechanism for the high thrombotic tendency?},
  author={J P Colle and Zohar Mishal and Claude Lesty and Manouchehr Mirshahi and J Peyne and Alain Baumelou and Albert Bensman and Jeannette Soria and C. I. M. A. Arturo Soria},
  journal={Thrombosis and haemostasis},
  year={1999},
  volume={82 5},
  pages={1482-9}
}
Porosity, viscoelasticity and morphological properties of plasma fibrin from 16 nephrotic patients and 16 healthy volunteers were compared. Nephrotic patients were characterized by formation of tight and rigid plasma fibrin gels which resulted in a slower rate of fibrin lysis studied either under pressure-driven permeation or diffusional transport of fibrinolytic agents. These latter findings indicated that both abnormal fibrin network conformation and abnormal fibrin fiber structure were… CONTINUE READING

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