Abnormal fibrils from scrapie-infected brain

@article{Merz1981AbnormalFF,
  title={Abnormal fibrils from scrapie-infected brain},
  author={Patricia A. Merz and Robert A. Somerville and Henryk M. Wiśniewski and Khalid Iqbal},
  journal={Acta Neuropathologica},
  year={1981},
  volume={54},
  pages={63-74}
}
Abnormal fibrillary structures, designated “scrapie-associated fibrils” (SAF), have been observed using negative stain techniques in subfractions of brains from scrapie-affected animals. SAF have been observed in all combinations of strain of scrapie agent and strain or species of host examined, regardless of their histopathology, in particular the presence or absence of amyloid plaques. SAF consist either of two or four filaments. They are morphologically dissimilar to the normal brain fibrils… CONTINUE READING

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